config_data.php

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<?php
use Magento\Config\Model\Config\Factory;
use Magento\TestFramework\Helper\Bootstrap;

$objectManager = Bootstrap::getObjectManager();

$configFactory = $objectManager->create(Factory::class);
$config = $configFactory->create();
$config->setScope('stores');
$config->setStore('default');
$config->setDataByPath('design/header/welcome', null);
$config->save();